Chemical reprogramming and transdifferentiation
نویسندگان
چکیده
منابع مشابه
Dedifferentiation, transdifferentiation, and reprogramming: future directions in regenerative medicine.
The main goal of regenerative medicine is to replace damaged tissue. To do this it is necessary to understand in detail the whole regeneration process including differentiated cells that can be converted into progenitor cells (dedifferentiation), cells that can switch into another cell type (transdifferentiation), and somatic cells that can be induced to become pluripotent cells (reprogramming)...
متن کاملEpigenetic Regulation of B Lymphocyte Differentiation, Transdifferentiation, and Reprogramming
B cell development is a multistep process that is tightly regulated at the transcriptional level. In recent years, investigators have shed light on the transcription factor networks involved in all the differentiation steps comprising B lymphopoiesis. The interplay between transcription factors and the epigenetic machinery involved in establishing the correct genomic landscape characteristic of...
متن کاملGlobal Epigenetic State Network Governs Cellular Pluripotent Reprogramming and Transdifferentiation
Department of Biological Sciences, Virginia Tech, Blacksburg, VA 24060, USA Center for Complex Network Research, Departments of Physics, Biology, and Computer Science, Northeastern University, Boston, MA 02115, USA. Department of Medicine, Harvard Medical School, and Center for Cancer Systems Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. National Heart, Lung and Blood Institutes...
متن کاملExploring the Mechanisms of Differentiation, Dedifferentiation, Reprogramming and Transdifferentiation
We explored the underlying mechanisms of differentiation, dedifferentiation, reprogramming and transdifferentiation (cell type switchings) from landscape and flux perspectives. Lineage reprogramming is a new regenerative method to convert a matured cell into another cell including direct transdifferentiation without undergoing a pluripotent cell state and indirect transdifferentiation with an i...
متن کاملReprogramming with defined factors: from induced pluripotency to induced transdifferentiation.
Ever since work on pluripotency induction was originally published, reporting the reprogramming of somatic cells to induced pluripotent stem cells (iPS cells) by the ectopic expression of the four transcription factors Oct4, Sox2, Klf4 and c-Myc, high expectations regarding their potential use for regenerative medicine have emerged. Very recently, the direct conversion of fibroblasts into funct...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Opinion in Genetics & Development
سال: 2017
ISSN: 0959-437X
DOI: 10.1016/j.gde.2017.07.003